The MayoGC provides a model of a unique collaborative effort in the environment of a common EMR for the investigation of genetic determinants of diseases. The EMR consists of an abundance of phenotype data that can be extracted in a relatively quick and systematic manner. Large consortia with harmonized genotype data have been assembled to attain sufficient statistical power, but phenotyping remains a rate-limiting factor in gene discovery research efforts. CONCLUSION: Genome-wide association studies have identified genetic variants associated with numerous phenotypes but have been historically limited by inadequate sample size due to costly genotyping and phenotyping. RESULTS: Genome-wide significant results were observed on 2q37 (top single nucleotide polymorphism, rs4148325 P=5.0 × 10 –62) and 12p12 (top single nucleotide polymorphism, rs4363657 P=5.1 × 10 –8) corresponding to a gene cluster of uridine 5′-diphospho-glucuronosyltransferases (the UGT1A cluster) and solute carrier organic anion transporter family, member 1B1 ( SLCO1B1), respectively. A genome-wide association study to identify genetic variants associated with total bilirubin levels was conducted to test the genetic research capability of the MayoGC. Herein, we describe the design of the MayoGC, including the current participating cohorts, expansion efforts, data processing, and study management and organization.
PARTICIPANTS AND METHODS: Eligible participants include those who gave general research consent in the contributing studies to share high-throughput genotyping data with other investigators. After you are done installing the Autodesk Vault File Server, you must configure your server settings before you can begin using the Vault File Server.
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Autodesk Vault File Server cannot be installed on the same machine in which Autodesk Vault Professional Server is installed.Autodesk Vault File Server 2015 connects only to Autodesk Vault Professional Server 2015.
The Autodesk Vault File Server does not require database replication.
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This is a smaller and simpler deployment configuration than the full replication configuration with fast client access to remote meta-data and to local files. The Autodesk Vault File Server 2015 provides support for distributed teams by enabling remote locations.
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